It is well known that at the intersection of the life sciences and modern computational methods lies untapped potential for biological and biochemical discovery. The mission of this repository is to demystify this convergence, making powerful computational tools accessible to scientists of all backgrounds.
This website has been setup to help translate complex computational methods into practical applications for cellular studies and microscopy analysis. Whether you’re a seasoned researcher looking to expand your toolkit or wanting to take your first steps into working with computational methods, I am working to provide clear guidance for integrating these tools into your research workflow.
Breaking down computational concepts into the building blocks that resonate with scientists.
Focusing on real-world applications in microscopy and cellular studies, not just abstract ideas.
Connecting traditional biochemical and biological methods with modern computational approaches.
All the guides and projects on this site are designed with the bench scientist in mind.
I am a researcher with a passion for the life sciences as well as the ever evolving computational tools that can help us to innovate within the field. I started this site/lab primarily as a repository to dump my ideas, projects, and data I collect while working to setup my own interconnected workflow and space.
McCue, C.; Mersch, S.; Kay, T. M.; Boersma, A. J.; Sheets, E. D.; Heikal, A. A. 2024. Wavelength- dependent fluorescence fluctuation analysis of an mCerulean3-linker-mCitrine construct for environmental ionic strength sensing at the single-molecule level. Biophys. Journal. 123.
Mersch, S.; McCue, C.; Aristidou, A.; Sheets, E. D.; Boersma, A. J.; Heikal, A. A. 2024. Translational Diffusion, Molecular Brightness, and Energy Transfer Analysis of mEGFP–Linker– mScarlet–I Crowding Biosensor using Fluorescence Correlation Spectroscopy. Phys Chem Chem Phys.
McCue, C.; Mersch, S.; Bergman, S.; Sheets, E. D.; Heikal, A. A. 2023. Conformational equilibrium analysis of mCerulean3–linker–mCitrine constructs using time-resolved fluorescence measurements in controlled environments. Proc. SPIE. 1268107.